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Developmental and genetically predisposed abnormalities observed in the prefrontal and hippocampal regions in individuals with SZ may facilitate neural circuitry dysfunction, promoting a vulnerability toward addiction, such as tobacco use disorder (59)

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Over time, the regulatory system will need to move on from harm reduction (which forms the basis of the APPH test) to define a regulatory framework for the use of nicotine as a lawful, mildly psychoactive yet potentially addictive substance